Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of unilateral nephrectomy on vitamin D metabolism in pregnant rats

   
Ivashkevich S.P., Shirankova T.G., Apukhovskaia L.I., Omel'chenko L.I.
PubMed Id: 1492397
Year: 1992 vol: 38  issue:5  pages: 44-47
Abstract: Unilateral nephrectomy causes a decrease in provision of vitamin D dihydro derivatives in pregnant rats, which correlated with the development of hypocalcemia and hypophosphatemia as well as with an increased content of parathyroid hormone. Fetuses of these females contained less amount of mineral components and active metabolites of vitamin D. Neonates, being born by these females with the nephrectomy, had vitamin D deficiency, which was manifested as a decrease in content of active vitamin D metabolites and minerals as well as an increase in activity of alkaline phosphatase and in the content of parathyroid hormone.
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Reference: Ivashkevich S.P., Shirankova T.G., Apukhovskaia L.I., Omel'chenko L.I., The effect of unilateral nephrectomy on vitamin D metabolism in pregnant rats, Voprosy meditsinskoi khimii, 1992, vol: 38(5), 44-47.
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