Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibiting effect of domestic, synthetic beta-carotene and ascorbic acid on endogenous carcinogenesis in mice

   
Sergeeva T.I., Vakulova L.A., Zhidkova T.A., Sergeev A.V.
PubMed Id: 1298116
Year: 1992 vol: 38  issue:6  pages: 12-14
Abstract: Carcinogenesis in mice induced by the tryptophane derivative 3-hydroxyanthranilic acid was studied after administration of synthetic beta-carotene and ascorbic acid. The incidence of induced hemoblastoses and hepatomas was decreased 2-fold, while the latent period of their development was, increased in mice on a lifetime feed containing 15 mg/kg of beta-carotene. The anticarcinogenic effect of ascorbic acid added to drinking water was similar to that of beta-carotene. The additive inhibitory influence of beta-carotene and ascorbic acid on endogenous blastomogenesis was not found in mice.
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Reference: Sergeeva T.I., Vakulova L.A., Zhidkova T.A., Sergeev A.V., Inhibiting effect of domestic, synthetic beta-carotene and ascorbic acid on endogenous carcinogenesis in mice, Voprosy meditsinskoi khimii, 1992, vol: 38(6), 12-14.
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