Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antimutagenic properties of substances containing beta-carotene

   
Shliankevich M.A., Drize O.B., Khabibulina V.M., Sergeev A.V., Privalova E.G., Nikitiuk V.G.
PubMed Id: 1298121
Year: 1992 vol: 38  issue:6  pages: 23-25
Abstract: Two carotene-containing drugs (natural and artificial) were shown to decrease the rate of chromosomal aberrations, induced by cyclophosphane, in bone marrow cells of mice, daily ration of which contained 10-20 mg/kg of beta-carotene within 1-3 weeks. The rate of chromosomal aberrations induced was decreased 1.5-2-fold in various experiments. Artificial beta-carotene exhibited aftereffect within at least 3 days, while its protective effect was decreased about by 20% within 7 days after administration.
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Reference: Shliankevich M.A., Drize O.B., Khabibulina V.M., Sergeev A.V., Privalova E.G., Nikitiuk V.G., Antimutagenic properties of substances containing beta-carotene, Voprosy meditsinskoi khimii, 1992, vol: 38(6), 23-25.
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