Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of beta-carotene on interleukin-2 production and mitogen-induced proliferation of T-lymphocytes

   
Buiuklinskaia O.V., Korostelev S.A., Potapova A.A., Sergeev S.A., Uteshev B.S.
PubMed Id: 1298124
Year: 1992 vol: 38  issue:6  pages: 29-31
Abstract: Interleukin-2 (IL-2) production followed by with aftereffect of the immunosuppressive agent hydrocortisone and mitogen-induced proliferation of T lymphocytes were studied in the presence of artificial beta-carotene. Treatment of CBA mice with the drug was performed within various periods. beta-Carotene was found to elevate IL-2 secretion and the effect was both time- and dose-dependent. The drug removed immunosuppression developed after intraperitoneal administration of hydrocortisone. At the same time, beta-carotene stimulated mitogen-induced proliferation of T cells, which was dose-dependent.
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Reference: Buiuklinskaia O.V., Korostelev S.A., Potapova A.A., Sergeev S.A., Uteshev B.S., The effect of beta-carotene on interleukin-2 production and mitogen-induced proliferation of T-lymphocytes, Voprosy meditsinskoi khimii, 1992, vol: 38(6), 29-31.
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