Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of administration of beta-carotene in an oil solution on its blood serum level and antioxidant status of patients with duodenal ulcer and erosive gastritis

   
Spirichev V.B., Levachev M.M., Rymarenko T.V., Iakushina L.M., Kharitonchik L.A., L'vovich N.A., Karagodina Z.V., Lupinovich V.L., Loranskaia T.I., Lebedeva R.P.
PubMed Id: 1298131
Year: 1992 vol: 38  issue:6  pages: 44-47
Abstract: Adequately good consumption of beta-carotene was observed in patients with duodenal ulcer and erosive gastritis after daily treatment with 18 mg of the carotinoid used as 0.1% oil solution: concentration of beta-carotene was increased approximately 3-fold in blood serum of these patients. Concentration of retinol was not increased in blood serum after treatment with beta-carotene, thus indicating that the drug treatment was not dangerous. Treatment with beta-carotene led to improvement in the state of the antioxidative system of these patients as resistance of erythrocytes to peroxide hydrolysis was increased while content of malonic dialdehyde was decreased in blood serum. The carotene treatment contributed to arresting pain syndrome in patients with ulcers, to cicatrization of ulcers and to disappearance of gastric mucosal membrane erosion.
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Reference: Spirichev V.B., Levachev M.M., Rymarenko T.V., Iakushina L.M., Kharitonchik L.A., L'vovich N.A., Karagodina Z.V., Lupinovich V.L., Loranskaia T.I., Lebedeva R.P., The effect of administration of beta-carotene in an oil solution on its blood serum level and antioxidant status of patients with duodenal ulcer and erosive gastritis, Voprosy meditsinskoi khimii, 1992, vol: 38(6), 44-47.
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