Voprosy meditsinskoi khimii (ISSN 0042-8809)

Possible reasons for bilirubin accumulation in the brain of newborn animals during oxygen deficiency

   
Tkachenko A.V.
PubMed Id: 1298136
Year: 1992 vol: 38  issue:6  pages: 56-60
Abstract: An increase in content of bilirubin was detected in brain tissue of newborn rats with chronic interrupted hypoxic hypoxia occurred during pre- and neonatal periods. Accumulation of bilidiene in animal brain tissues appears to occur due to the following causative factors: tissue acidosis, developed after oxygen deficiency, contributed to binding of bile pigment to brain cell plasma membranes, synaptosomal ones in particular; serum albumin lost its specific ability to bind bilirubin due to protein molecular accumulation of excessive fatty acids and acetaldehyde, which are bound to protein, as well as other minor ligands extracted by organic solvents.
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Reference: Tkachenko A.V., Possible reasons for bilirubin accumulation in the brain of newborn animals during oxygen deficiency, Voprosy meditsinskoi khimii, 1992, vol: 38(6), 56-60.
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