Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of 5'-nucleotidase from thymus and tumors upon administering bradykinin to tumor-bearing mice

   
Sukhanova G.A., Potanova G.V., Narbutovich S.A.
PubMed Id: 8511876
Year: 1993 vol: 39  issue:2  pages: 13-15
Abstract: Activity of 5'-nucleotidase was inhibited in thymus tissue of tumor-bearing mice; bradykinin (1 mg/kg body weight) increased the enzymatic activity 2.0-2.2-fold. Administration of bradykinin led to inhibition of allogenic Crocker's sarcoma growth and to stimulation of syngeneic mastocytoma P-815 growth, which was inoculated into noninbred and BALB/c mice, respectively. Hence, bradykinin activated 5'-nucleotidase in Crocker's sarcoma and did not affect the enzymatic activity in tumor P-815. This suggests that activity of 5'-nucleotidase is of importance in evaluation of the thymus tissue state as well as it demonstrates the tumoral tissue sensitivity to bradykinin.
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Reference: Sukhanova G.A., Potanova G.V., Narbutovich S.A., Activity of 5'-nucleotidase from thymus and tumors upon administering bradykinin to tumor-bearing mice, Voprosy meditsinskoi khimii, 1993, vol: 39(2), 13-15.
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