Voprosy meditsinskoi khimii (ISSN 0042-8809)

Interaction of NAD with the GABA-ergic system of the rat brain

   
Fomenko A.I., Parkhomets P.K., Donchenko G.V., Stepanenko S.P.
PubMed Id: 8390124
Year: 1993 vol: 39  issue:2  pages: 21-23
Abstract: After administration of corazole content of gamma-aminobutyric acid (GABA) was increased in the rat brain within 2 min and 10 min by 28% and 80%, respectively. Content of the GABA was distinctly decreased in the prespastic phase. During this period specific binding of 3H-muscimol to the GABA receptors was decreased. NAD at concentrations 10(-6) M and 10(-7) M activated the GABA receptors and inhibited binding of 14C-GABA to the synaptosomes of both intact rats and the animals treated with the convulsant agent. NAD appears to cause an effect as an inhibitory neurotransmitter at the postsynaptic level.
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Reference: Fomenko A.I., Parkhomets P.K., Donchenko G.V., Stepanenko S.P., Interaction of NAD with the GABA-ergic system of the rat brain, Voprosy meditsinskoi khimii, 1993, vol: 39(2), 21-23.
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