Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of NAD and cytochrome C on the energy supply system and ultrastructure of cardiomyocytes in toxic-allergic myocarditis

   
Karsanov N.V., Gogiashvili L.E., Selikhova E.V.
PubMed Id: 8390125
Year: 1993 vol: 39  issue:2  pages: 50-55
Abstract: The level of NAD was decreased while the NADH/NAD ratio was increased in the myocardium of rabbits with 10-day toxic-allergic myocarditis. The concentrations of ATP, ADP, AMP and especially of creatine phosphate were decreased in the myocardium. At the same time, inter- and intracellular edema was developed and the cardiomyocyte structure was impaired. After administration of NAD in a dose of 0.5 mg/kg of body mass, the content and ratio of pyridine nucleotides as well as content of ATP and AMP were completely normalized, while content of ADP exceeded the control values but creatine phosphate was maintained at a low level. Cardiomyocytic ultrastructure was distinctly improved. Cytochrome c, administered at a dose of 5 mg/kg of body mass, did not affect markedly the pyridine nucleotides ratio but increased slightly their total content. The adenylic nucleotides and creatine phosphate were distinctly increased as well as cardiomyocyte ultrastructure was considerably improved.
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Reference: Karsanov N.V., Gogiashvili L.E., Selikhova E.V., Effect of NAD and cytochrome C on the energy supply system and ultrastructure of cardiomyocytes in toxic-allergic myocarditis, Voprosy meditsinskoi khimii, 1993, vol: 39(2), 50-55.
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