Voprosy meditsinskoi khimii (ISSN 0042-8809)

DNA-binding blood proteins in hemoblastoses

Egorova V.A., Blinov M.N.
PubMed Id: 8333190
Year: 1993 vol: 39  issue:3  pages: 36-38
Abstract: Some differences were detected in the spectrum of DNA-binding proteins in blood serum of healthy volunteers and of patients with various forms of hemoblastoses. Two fractions of high molecular mass proteins were found to be main components of DNA-binding proteins in blood serum of both healthy persons and these patients. The DNA-binding proteins with a molecular mass less than 150 kDa were not detected under conditions of normal state, in myeloblast and lymphoblast forms of acute leukemia and in chronic phase of chronic myeloleukemia. However, additional fraction of DNA-binding proteins about 30-40 kDa was found in blast crisis of chronic myeloleukemia and in refractory anemia with increase of blast forms.
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Reference: Egorova V.A., Blinov M.N., DNA-binding blood proteins in hemoblastoses, Voprosy meditsinskoi khimii, 1993, vol: 39(3), 36-38.