Voprosy meditsinskoi khimii (ISSN 0042-8809)

Fatty acid composition and functional status of erythrocyte membranes in patients with sepsis

   
Soboleva M.K., Sharapov V.I.
PubMed Id: 8279133
Year: 1993 vol: 39  issue:5  pages: 19-21
Abstract: Distinct alterations in fatty acid composition and in the functional state of erythrocyte membranes were detected in 58 patients with sepsis; these alterations were phase-dependent and correlated highly with clinical picture. Considerable increase in content of saturated and monounsaturated fatty acids and a decrease in concentration of lipoproteins were found in erythrocyte membranes under inauspicious conditions of sepsis development. In these patients activities of superoxide dismutase and glucose-6-phosphate dehydrogenase were decreased, while content of SH-groups was lowered and lipid peroxidation was inhibited. The alterations observed in fatty acid composition of erythrocyte membranes and a decrease in metabolic activity of red blood cells may be responsible for hemolysis in patients with sepsis.
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Reference: Soboleva M.K., Sharapov V.I., Fatty acid composition and functional status of erythrocyte membranes in patients with sepsis, Voprosy meditsinskoi khimii, 1993, vol: 39(5), 19-21.
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