Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of liposome phospholipids in collagen-induced platelet aggregation

   
Zakrevskiĭ V.I., Kubatiev A.A., Galaev Yu.V.
PubMed Id: 8279135
Year: 1993 vol: 39  issue:5  pages: 21-23
Abstract: Influence of the charge-bearing phospholipids containing in liposome membrane on collagen-induced platelet aggregation was studied. The aggregation was inhibited after preincubation of blood platelets with liposomes containing egg lecithin/cholesterol/phosphatidylserine (stearyl amine); the effect was dose-dependent. Phosphatidylinositol incorporated into liposomes did not affect distinctly thrombocytes activation but decreased the rate of cell disaggregation; this effect was also dose-dependent. Use of phosphatidylinositol containing liposomes did not affect the content of thromboxane and prostacyclin in the system. The effect of the charge-bearing phospholipids on platelet aggregation observed should be considered in production of medicinal drugs.
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Reference: Zakrevskiĭ V.I., Kubatiev A.A., Galaev Yu.V., The effect of liposome phospholipids in collagen-induced platelet aggregation, Voprosy meditsinskoi khimii, 1993, vol: 39(5), 21-23.
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