Voprosy meditsinskoi khimii (ISSN 0042-8809)

The status of the adenylate cyclase system in rat myocardium in dystrophic degeneration

   
Kozlov A.V.
PubMed Id: 8279136
Year: 1993 vol: 39  issue:5  pages: 23-26
Abstract: Development of myocardial dystrophy, occurred after left-lateral vagotomy, aorta coarctation and novodrine administration, was accompanied by impairments in the adenylate cyclase system of rat myocardium at the step of secondary messenger production (cAMP) managed by adenylate cyclase of outer membranes. Dystrophic degenerations appear to depend on the type of deteriorations in intracellular enzymatic systems, which are regulated by cAMP, as shown by dissimilar response of myocardium to the agonist effect; this effect was increased in dystrophy caused by denervation and was altered only slightly after aorta coarctation and novodrine administration.
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Reference: Kozlov A.V., The status of the adenylate cyclase system in rat myocardium in dystrophic degeneration, Voprosy meditsinskoi khimii, 1993, vol: 39(5), 23-26.
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