Voprosy meditsinskoi khimii (ISSN 0042-8809)

Modification of complement components under the effect of cationic proteins from leukocytes from donors and leukemia patients

   
Rybakova L.P., Tiagotin Yu.V., Goncharova S.V., Kulikova I.N., Trofimov A.V.
PubMed Id: 8279141
Year: 1993 vol: 39  issue:5  pages: 38-41
Abstract: Cation proteins (CP) were isolated from leukocytes by means of ion exchange chromatography. Enzyme immunoassay showed that these cation proteins modified C3 component of complement in vitro. CP obtained from healthy volunteers decreased the content of C3 purified by affinity chromatography and C3 of blood serum; however, content of C3.H2O op C3b-like form and C3a-fragment were not altered. Effect of CP isolated from leukocytes of patients with chronic myeloleukemia and chronic lympholeukemia on C3 component was less distinct as compared with that of healthy volunteers. At the same time, content of C3b-like form was increased the presence of CP from patients with myeloleukemia and of C3a-fragment--in the presence of the proteins from patients with lympholeukemia. Excess of physiologically active C3 fragments, developed under conditions of these diseases, may contribute to a decrease in unspecific body resistance.
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Reference: Rybakova L.P., Tiagotin Yu.V., Goncharova S.V., Kulikova I.N., Trofimov A.V., Modification of complement components under the effect of cationic proteins from leukocytes from donors and leukemia patients, Voprosy meditsinskoi khimii, 1993, vol: 39(5), 38-41.
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