Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of disruption of lipid metabolism in mechanisms of the hepatotoxic effects of cisplatin

   
Vetoshkina T.V., Dubskaia T.Yu.
PubMed Id: 8303866
Year: 1993 vol: 39  issue:6  pages: 23-26
Abstract: Distinct alterations in the metabolism of lipids and phospholipids as well as activation of lipid peroxidation in liver tissue were detected in mice after administration of a new antitumoral drug cisplatin at a dose of LD50 (13.5 mg/kg) or after the course treatment within 5 days using 1/5 LD50. Content of malonic dialdehyde, diene conjugates and Schiff bases was increased, while the phospholipid composition was altered and concentration of membrane-toxic ingredients was increased. When the effects of cisplatin, administered at a dose of LD50 and during the course treatment, were analyzed more pronounced impairments of lipid metabolism were found during 7-15 days in mice treated with the drug at LD50. However, the drug toxic effect was manifested earlier during the course of treatment and in some cases it maintained for a long time (up to 30 days of the experiment). The data obtained suggest that correction of the cytostatic-induced impairments in liver tissue functions may be carried out by means of the anti-radical drugs.
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Reference: Vetoshkina T.V., Dubskaia T.Yu., The role of disruption of lipid metabolism in mechanisms of the hepatotoxic effects of cisplatin, Voprosy meditsinskoi khimii, 1993, vol: 39(6), 23-26.
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