Voprosy meditsinskoi khimii (ISSN 0042-8809)

The use of sodium gamma-oxybutyrate and gutimine for decreasing metabolic disorders in the heart, caused by exotoxic shock in acetic acid poisoning

   
Petrin I.N., Dolgikh V.T., Krolevets I.P.
PubMed Id: 8303871
Year: 1993 vol: 39  issue:6  pages: 36-39
Abstract: Exotoxic shock was simulated in non-linear rat males anesthetized with barbital after intragastric administration of 70% acetic acid at a dose of 4 ml/kg using a gastric tube. Energy metabolism and the rate of lipid peroxidation were studied in heart muscle during the decompensated and terminal periods of exotoxic shock. Sodium hydroxybutyrate (200 mg/kg) and gutimine (75 mg/kg), administered alone within 30 min after the poisoning, prolonged the period before manifestation of the decompensated and terminal steps of the shock; these drugs decreased the rate of metabolic impairments in the myocardium by decreasing the rates of adenine nucleotide catabolism, of glycolysis, lipolysis and lipid peroxidation.
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Reference: Petrin I.N., Dolgikh V.T., Krolevets I.P., The use of sodium gamma-oxybutyrate and gutimine for decreasing metabolic disorders in the heart, caused by exotoxic shock in acetic acid poisoning, Voprosy meditsinskoi khimii, 1993, vol: 39(6), 36-39.
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