Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effects of synergism during combined antioxidant action of phosphatidylcholine with natural and synthetic quinones

   
Storozhok N.M., Drulle A.Ya., Login Ya.Ya., Dregeris Ya.Ya., Burlakova E.B., Khrapova N.G.
PubMed Id: 8122398
Year: 1994 vol: 40  issue:1  pages: 10-14
Abstract: The combined action of ovarian phosphatidylcholine and phylloquinone (vitamin K1), menadione, artificial analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl-1,4-naphthoquinone (AK-40, AK-49) recommended as promising membrane protectors was studied. Synergic effects were detected in the antioxidant action of the quinones studied and phosphatidylcholine; AK-40 was the most effective in the presence of phosphatidylcholine. The synergic effect correlated with the concentrations of the antioxidants. Alterations in the synergism, which depended on phosphatidylcholine concentrations, were similar for all the inhibitors studied: the effect was proportionally increased with the elevation of phosphatidylcholine concentrations in the mixture up to 2.5 x 10(-3) M and then the synergic effect was unaltered during the further increase in phosphatidylcholine content.
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Reference: Storozhok N.M., Drulle A.Ya., Login Ya.Ya., Dregeris Ya.Ya., Burlakova E.B., Khrapova N.G., Effects of synergism during combined antioxidant action of phosphatidylcholine with natural and synthetic quinones, Voprosy meditsinskoi khimii, 1994, vol: 40(1), 10-14.
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