Voprosy meditsinskoi khimii (ISSN 0042-8809)

Enterosorbent with immobilized trimethylaminoethanol chloride. I. hypolipidemic properties

   
Lopukhin Yu.M., Andrianova I.P., Ryzhenkov V.E., Samoĭlova N.A., Chistiakova A.M., Frolova Yu.V., Iamskov I.A., Sergienko V.I., Lapuk Ya.I.
PubMed Id: 8122401
Year: 1994 vol: 40  issue:1  pages: 18-20
Abstract: Hypolipidemic properties of the synthesized enterosorbent, water soluble polymer containing covalently immobilized trimethylamine ethanol chloride, were studied. Content of cholesterol in blood was decreased by 29% and accumulation of cholesterol in liver tissue--by 22% after oral administration of the enterosorbent at a dose of 250 mg/kg into rats with hypercholesterolemia. Cholestyramine exhibited the similar effect only at a dose of 2.5 g/kg. Except for the hypocholesterolemic effect, the enterosorbent altered also the lipoprotein spectrum in rat blood serum.
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Reference: Lopukhin Yu.M., Andrianova I.P., Ryzhenkov V.E., Samoĭlova N.A., Chistiakova A.M., Frolova Yu.V., Iamskov I.A., Sergienko V.I., Lapuk Ya.I., Enterosorbent with immobilized trimethylaminoethanol chloride. I. hypolipidemic properties, Voprosy meditsinskoi khimii, 1994, vol: 40(1), 18-20.
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