Voprosy meditsinskoi khimii (ISSN 0042-8809)

Change in the oxidative metabolism of macrophages during transformation into foam cells

   
Zenkov N.K., Dushkin M.I., Liubimov G.Iu., Men'shchikova E.B.
PubMed Id: 8122402
Year: 1994 vol: 40  issue:1  pages: 2-4
Abstract: Oxidative metabolism of murine peritoneal macrophages was studied after cultivation in a mixture containing acetylated low density lipoproteins within 24 and 48 hr using luminol- and lucigenin-dependent chemiluminescence. Chemiluminescence of foamy cells, induced by opsonized zymosan, was not distinctly altered as compared with native macrophages; at the same time, the rate of both lucigenin- and luminol-dependent spontaneous chemiluminescence was distinctly decreased. The imbalance of the oxidative reactions observed enables the authors to propose the antioxidative mechanism of atherosclerotic lesion.
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Reference: Zenkov N.K., Dushkin M.I., Liubimov G.Iu., Men'shchikova E.B., Change in the oxidative metabolism of macrophages during transformation into foam cells, Voprosy meditsinskoi khimii, 1994, vol: 40(1), 2-4.
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