Voprosy meditsinskoi khimii (ISSN 0042-8809)

Status of nucleic acid and total protein synthesis in hematopoietic organs in mice with alloxan diabetes

   
Kozlov Yu.A., Volkova N.P., Baĭkov A.N., Novitskiĭ V.V.
PubMed Id: 7512777
Year: 1994 vol: 40  issue:2  pages: 19-21
Abstract: Rates of 3H-thymidine, 3H-uridine and 14C-glycine incorporation in nucleic acids and total proteins were studied in cells of bone marrow, spleen, thymus and ileocecal lymph nodes tissues of BALB/c mice with subacute alloxan diabetes (content of blood sugar was higher than 14 mmol/l). Synthesis of DNA, RNA and protein was not considerably inhibited in the thymus tissue of the impaired animals which may correlate with pronounced dysfunction of cytotoxic T lymphocytes typical for the disease.
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Reference: Kozlov Yu.A., Volkova N.P., Baĭkov A.N., Novitskiĭ V.V., Status of nucleic acid and total protein synthesis in hematopoietic organs in mice with alloxan diabetes, Voprosy meditsinskoi khimii, 1994, vol: 40(2), 19-21.
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