Voprosy meditsinskoi khimii (ISSN 0042-8809)

An endogenous activator of angiotensin-converting enzyme

   
Eliseeva Yu.E., Pavlikhina L.V., Shavgulidze T.V., Messina E., Dzhakonello A., Salerno K., Perrikone R.
PubMed Id: 8079436
Year: 1994 vol: 40  issue:3  pages: 35-37
Abstract: An endogenous activator of the angiotensin-converting enzyme (ACE), unknown earlier, was detected in freshly prepared human neutrophils. Supernatants of the neutrophil suspension produced a 1.6-2-fold activation of the ACE isolated from bovine kidney cortex. The ACE activating effect of these supernatants correlated with concentration of neutrophils in the initial suspension. The activator did not penetrate through membranes of Centricon-30. This activator was also found in blood serum of patients with hereditary deficiency of the complement CI-esterase inhibitor. The neutrophil-released ACE activator is likely to be involved in the modulation of inflammatory responses.
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Reference: Eliseeva Yu.E., Pavlikhina L.V., Shavgulidze T.V., Messina E., Dzhakonello A., Salerno K., Perrikone R., An endogenous activator of angiotensin-converting enzyme, Voprosy meditsinskoi khimii, 1994, vol: 40(3), 35-37.
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