Voprosy meditsinskoi khimii (ISSN 0042-8809)

Use of electron paramagnetic resonance in assessing viscosity of blood lipids in diabetes mellitus in children

   
Turkina T.I., Marchenko L.F., Timofeev K.N., Ovchinnikova N.V., Baturin A.A.
PubMed Id: 7975379
Year: 1994 vol: 40  issue:4  pages: 38-40
Abstract: Viscosity of blood serum lipids was studied in children with insulin-dependent diabetes involving nitroxyl containing probes-registered by means of radiospectrometer RE 1307. The following parameters were studied: the ratios between values exhibiting the probe distribution in polar and hydrophobic phases [formula: see text] as well as between content of low polar (I+1) and high polar (I-1) spectral components. The "f' value showed the state of lipid density and the ratio [formula: see text] allowed to estimate the lipid microviscosity. 34 children of 7-15 years old with insulin-dependent diabetes were examined in dynamics of treatment under stationary conditions. Distinct metabolic impairments and aggravation of the lipid peroxidation syndrome were mainly responsible for pronounced increase in lipid viscosity. The procedure of spin probes may contribute to study of diabetes pathogenesis as well as to serve as a diagnostic means in evaluation of the disease complications at early stages.
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Reference: Turkina T.I., Marchenko L.F., Timofeev K.N., Ovchinnikova N.V., Baturin A.A., Use of electron paramagnetic resonance in assessing viscosity of blood lipids in diabetes mellitus in children, Voprosy meditsinskoi khimii, 1994, vol: 40(4), 38-40.
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