Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of ionizing radiation on human muscle tissue

   
Kondakova N.V., Lisakovskiĭ S.V., Sakharova V.V., Koroleva O.A., Dubinskaia V.A., Nikolaeva S.S.
PubMed Id: 7975381
Year: 1994 vol: 40  issue:4  pages: 46-50
Abstract: The effect of ionizing radiation (gamma-irradiation of 60Co, doses from 10 Gy to 15 kGy) on human muscle tissue was studied using a biopsy material. Destructive alterations in muscle proteins were observed beginning from the dose of 1.0 kGy: appearance of new protein fractions with molecular mass 68-160 kDa and 18-36 kDa. Resistance of muscle proteins to the trypsin effect was unaltered, while the rate of pronase-induced hydrolysis was slightly increased, about 1.2-fold. Content of water and biomechanical properties of the tissue were unaltered, but the modulus of elasticity was decreased approximately 3-fold after treatment with maximal doses of the ionizing radiation used.
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Reference: Kondakova N.V., Lisakovskiĭ S.V., Sakharova V.V., Koroleva O.A., Dubinskaia V.A., Nikolaeva S.S., The effect of ionizing radiation on human muscle tissue, Voprosy meditsinskoi khimii, 1994, vol: 40(4), 46-50.
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