Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of emotional-painful stress, hypoxia, and adaptation to it on the activity of enzymes for metabolizing glutathione and concentration of glutathione in rat organs

   
Kolesnichenko L.S., Kulinsky V.I., Ias'ko M.V., Ekimov E.N., Stanevich L.M., Glushkova E.F., Belogorov S.B., Filippova G.T.
PubMed Id: 7839657
Year: 1994 vol: 40  issue:5  pages: 10-12
Abstract: The stress activates glutathione peroxidase in the heart, liver, and kidney, glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the liver; the activity of glutathione reductase and the content of reduced glutathione were unchanged. Two-four-minute hypercapnic hypoxia unchanged the activity of glutathione metabolic enzymes. The activity of the above enzymes decreases in some organs at the death caused by 2-15-minute hypoxia. Long-term intermittent adaptation to hypobaric hypoxia lowers the activity of glutathione peroxidase, -transferase and -reductase. The biological value of the two types of enzymatic responses may be different: stress-induced activation of glutathione metabolic enzymes can enhance resistance to stress and xenobiotics; however, their inhibition during hypoxic adaptation may produce the opposite effect
Download PDF:
Reference: Kolesnichenko L.S., Kulinsky V.I., Ias'ko M.V., Ekimov E.N., Stanevich L.M., Glushkova E.F., Belogorov S.B., Filippova G.T., The effect of emotional-painful stress, hypoxia, and adaptation to it on the activity of enzymes for metabolizing glutathione and concentration of glutathione in rat organs, Voprosy meditsinskoi khimii, 1994, vol: 40(5), 10-12.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)