Voprosy meditsinskoi khimii (ISSN 0042-8809)

Ubiquinones and the body's antimutagenic defense

   
Georgiev V.N., Durnev A.D., Seredenin S.B.
PubMed Id: 7839677
Year: 1994 vol: 40  issue:5  pages: 8-9
Abstract: The effects of ubiquinone-10 given in oral doses of 0.2-20 mg/kg on cytogenetic effects of intraperitoneal photrinum (7 and 14 mg/kg), dioxydinum (100 and 300 mg/kg) and cyclophosphanum (20 mg/kg) were studied in the bone marrow metaphasic cells of male C57Bl/6 mice. Ubiquinone-10 (2 to 20 mg/kg) statistically significantly reduced the clastogenic action of these mutagens, except photrinum used in a dose of 7 mg/kg. The antimutagenic effect of the drug was dose-independent and no more than 50%. The findings enable ubiquinone-10 be considered as an endogenous antimutagen. It is suggested that the antimutagenic activity of the compound is due to its antioxidative properties
Download PDF:
Reference: Georgiev V.N., Durnev A.D., Seredenin S.B., Ubiquinones and the body's antimutagenic defense, Voprosy meditsinskoi khimii, 1994, vol: 40(5), 8-9.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)