Voprosy meditsinskoi khimii (ISSN 0042-8809)

Factors affecting the concentration of serum ceruloplasmin in Wilson-Konovalov disease

   
Mzhel'skaia T.I., Ivanova-Smolenskaia I.A., Korobova N.V.
PubMed Id: 7618303
Year: 1994 vol: 40  issue:6  pages: 48-53
Abstract: An oxidase activity of ceruloplasmin was studied in blood serum of 335 patients with Wilson-Konovalov disease before specific copper-obviating treatment. Coefficient for calculation of concentration units depending on optic density was estimated by means of copper content measurement in ceruloplasmin. The well-known fact of ceruloplasmin content decrease in the Wilson-Konovalov disease was supplemented by the new data involving age-sex differences and the age-dependent dynamics as compared with healthy persons and with a group of 827 patients with other neurological diseases. Under conditions of the pathology concentration of ceruloplasmin was minimal in teenagers and in men it was lower than in women (62.1 +/- 4.0% and 88.2 +/- 5.0%, respectively, P < 0.001). Statistically distinct differences in content of ceruloplasmin were found in the patients of 15-19 years old and 20-24 years old as compared with the older age groups. Higher content of ceruloplasmin, exceeding the normal level about 200 mg/l, was most often detected at the preneurological step of the disease as compared with the neurological period (8.8% and 2.3%, respectively)
Download PDF:
Reference: Mzhel'skaia T.I., Ivanova-Smolenskaia I.A., Korobova N.V., Factors affecting the concentration of serum ceruloplasmin in Wilson-Konovalov disease, Voprosy meditsinskoi khimii, 1994, vol: 40(6), 48-53.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)