Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antioxidant activity of natural and synthetic quinones

   
Storozhok N.M., Drulle A.Ya., Login I.Ya., Dregeris I.Ya., Khrapova N.G., Burlakova E.B.
PubMed Id: 7771081
Year: 1995 vol: 41  issue:1  pages: 16-21
Abstract: Antioxidation activity (AOA) of ubiquinone (Q10), phylloquinone (vitamin K1), menadione as well as of the newly synthesized analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl 1.4-naphthoquinone, producing autocomplexes with intramolecular transfer of electrons, was studied in the model system of the methyl oleate initiated oxidation. The menadione AOA was shown to be 2-fold higher as compared with the inhibitory activity of natural quinones. Activity of AK-40 and AK-49, artificial analogues of vitamin K1, was higher 2.6-fold than that of ubiquinone and phylloquinone and 1.4-fold higher than menadione activity. At the same time, AOA of ubiquinone and phylloquinone was 1.5-fold lower than the tocopherol activity, while naphthoquinones AK-40 and AK-49 were 2-fold more active as compared with tocopherol but their activity was 2-fold lower than ionol. Mechanism of natural and synthetic quinones action as well as properties of their long chain analogues are discussed
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Reference: Storozhok N.M., Drulle A.Ya., Login I.Ya., Dregeris I.Ya., Khrapova N.G., Burlakova E.B., Antioxidant activity of natural and synthetic quinones, Voprosy meditsinskoi khimii, 1995, vol: 41(1), 16-21.
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