Voprosy meditsinskoi khimii (ISSN 0042-8809)

Correcting effect of nicotinamide on hemoglobin glycosylation in streptozotocin diabetes in rats

   
Velikiĭ N.N., Burda V.A., Obrosova I.G., Biront N.V., Fedyk M.Ya.
PubMed Id: 7771089
Year: 1995 vol: 41  issue:1  pages: 36-38
Abstract: Streptozotocin induced diabetes in rats was accompanied by development of hyperglycemia, by increase in the rate of hemoglobin and albumin glycosylation in blood and by elevation of 2,3-diphosphoglycerate content in erythrocytes. Alterations of the dissociation properties and the decrease in Hb P50 value suggested the reduced affinity of hemoglobin to oxygen. Injection of nicotinamide, which is involved in NAD+ biosynthesis, caused a decrease of glucose content in blood, stabilized the content of 2,3-diphosphoglycerate and of glycosylated hemoglobin in erythrocytes. Nicotinamide appears to decrease the rate of hemoglobin glycosylation and enhanced the tissue oxygen utilization under hypoxic conditions.
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Reference: Velikiĭ N.N., Burda V.A., Obrosova I.G., Biront N.V., Fedyk M.Ya., Correcting effect of nicotinamide on hemoglobin glycosylation in streptozotocin diabetes in rats, Voprosy meditsinskoi khimii, 1995, vol: 41(1), 36-38.
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