Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of Staphylococcus aureus toxic shock exotoxin on whole blood cell chemiluminescence in vitro and in vivo

   
Antipov A.Yu., Shepelev A.P., Poliakov V.M.
PubMed Id: 7793095
Year: 1995 vol: 41  issue:2  pages: 40-42
Abstract: Stimulated and nonstimulated blood chemiluminescence were studied in presence of the toxic shock syndrome toxin I (TSST-I) in vivo and in vitro. In vivo experiments involved evaluation of rabbit whole blood chemiluminescence developed within various periods after the TSST-I intraperitoneal administration. Effect of various TSST-I concentrations on blood chemiluminescence was studied in vitro. TSST-I was shown to inhibit the nonstimulated chemiluminescence in blood within 45 min after administration of LD50 of both opsonized zymosan and calcium ionophore A 23187 in vivo. Similar effects the toxin exhibited at concentrations 20 microM and more in vitro. The maximum effect TSST-I demonstrated within the first 5 min of incubation and this effect was distinctly dose-dependent
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Reference: Antipov A.Yu., Shepelev A.P., Poliakov V.M., The effect of Staphylococcus aureus toxic shock exotoxin on whole blood cell chemiluminescence in vitro and in vivo, Voprosy meditsinskoi khimii, 1995, vol: 41(2), 40-42.
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