Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of spermine on protein kinase activity and number of cytosolic estradiol receptors

   
Gevorkian E.S., Akopian N.R., Artsruni I.G., Iavorian Z.V.
PubMed Id: 8585179
Year: 1995 vol: 41  issue:3  pages: 41-42
Abstract: Spermine decreased distinctly the activity of Ca2+ -phospholipid-dependent protein kinases, whereas not affected the protein kinase A activity. Content of cytosol estradiol receptors was drastically decreased in rat uterine in presence of the polyamine. The data obtained and literature data suggest that activation of estradiol receptors appears to occur after phosphorylation by means of Ca2+ - dependent protein kinases, which are regulated via phosphoinositide-involving mechanism, i.e. these receptors acquire the ability to bind hormones
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Reference: Gevorkian E.S., Akopian N.R., Artsruni I.G., Iavorian Z.V., The effect of spermine on protein kinase activity and number of cytosolic estradiol receptors, Voprosy meditsinskoi khimii, 1995, vol: 41(3), 41-42.
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