Voprosy meditsinskoi khimii (ISSN 0042-8809)

Ability of bone marrow cells to generate active forms of oxygen in C57Bl/6 and BALB/C mice and mutagenic effects of dioxidine

   
Guseva N.V., Durnev A.D., Seredenin S.B.
Type: Experimental study
PubMed Id: 8571581
Year: 1995 vol: 41  issue:4  pages: 25-28
Abstract: Phorbol-myristate acetate- and opsonized zymosan-induced statistically significant differences were shown in the intensity of chemiluminescence occurring in the bone marrow cell suspension. The bone marrow cells from male BALB/c mice showed the most pronounced response to stimulation in the two cases. After 5-day administration of dioxidine (300 mg/kg), the number of the injured metaphases in the bone marrow from the examined animals was 43.6 +/- 2.2 and 23.8 +/- 1.9% in BALB/c and C57B1/6 mice, respectively, which provides evidence for marked strain-specific differences in the cytogenetic effect of this proxidative mutagen. The findings indicated that there was a relationship between the capacity of bone marrow cells of producing APA and the severity of cytogenetic lesions in these cells
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Reference: Guseva N.V., Durnev A.D., Seredenin S.B., Ability of bone marrow cells to generate active forms of oxygen in C57Bl/6 and BALB/C mice and mutagenic effects of dioxidine, Voprosy meditsinskoi khimii, 1995, vol: 41(4), 25-28.
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