Voprosy meditsinskoi khimii (ISSN 0042-8809)

Clastogenic activity of dietary sugar substitutes

   
Durnev A.D., Oreshchenko A.V., Kulakova A.V., Beresten N.F., Seredenin S.B.
Type: Experimental study
PubMed Id: 8571583
Year: 1995 vol: 41  issue:4  pages: 31-33
Abstract: The present paper describes the possible clastogenic activity of the following synthetic sugar substitutes, such as cyclamate in daily doses of 11 and 110 mg/kg, saccharin, 5 and 50 mg/kg, acesulfam, 15 and 150 mg/kg, sucralose, 15 and 150 mg/kg, aspartame, 40 and 400 mg/kg, orally given to C57Bl/6 mice during 5 days. No clastogenic activity was found in the compounds tested.
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Reference: Durnev A.D., Oreshchenko A.V., Kulakova A.V., Beresten N.F., Seredenin S.B., Clastogenic activity of dietary sugar substitutes, Voprosy meditsinskoi khimii, 1995, vol: 41(4), 31-33.
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