Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of blood antioxidant enzymes in chronic liver damage

   
Matiushin B.N., Loginov A.S., Iakimchuk G.N., Tkachev V.D.
Type:
PubMed Id: 8571591
Year: 1995 vol: 41  issue:4  pages: 54-56
Abstract: Patients with chronic hepatic disease have higher superoxide dismutase (SOD) activity and lower erythrocytic glutathione levels. There was a decrease in plasma SOD activity in cirrhosis, a feedback between the dismutase and oxidase activities of ceruloplasmin in cholestatic damages to the liver. Drug therapy resulted in positive dynamics in the levels of SOD, glutathione peroxidase, glutathione, ceruloplasmin, which is likely to be associated with the control of the enzymatic mechanisms of antioxidative protection. It is suggested that the enhanced erythrocytic SOD activity in hepatic diseases might trigger free radical oxidation
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Reference: Matiushin B.N., Loginov A.S., Iakimchuk G.N., Tkachev V.D., Activity of blood antioxidant enzymes in chronic liver damage, Voprosy meditsinskoi khimii, 1995, vol: 41(4), 54-56.
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