Voprosy meditsinskoi khimii (ISSN 0042-8809)

Analysis of cytogenetic activity of food dyes

   
Durnev A.D., Oreshchenko A.V., Kulakova A.V., Beresten N.F.
PubMed Id: 8553630
Year: 1995 vol: 41  issue:5  pages: 50-53
Abstract: The cytogenetic activity of food dyes was examined in the experiments on male C57B1/6 mice which were orally given during 5 days the following daily doses: Tartrasine (E102), 0.5 and 5.0 mg/kg; Indigo carmine (E132), 1.4 and 14 mg/kg; Canset yellow (E110), 0.17 and 1.7 mg/kg; Cochenillerot A (E124), 0.63 and 6.3mg/kg; Azorubin (E122), 1 and 10 mg/kg and Patentblau V (E131), 0.08 and 0.8 mg/kg. Five hundred metaphase slides each were analyzed in the control and experimental test series. The findings may conclude that the dyes tested within the above dose ranges do not induce any increase in the level of cells with chromosomal damages in the inbred animals
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Reference: Durnev A.D., Oreshchenko A.V., Kulakova A.V., Beresten N.F., Analysis of cytogenetic activity of food dyes, Voprosy meditsinskoi khimii, 1995, vol: 41(5), 50-53.
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