Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effects of cytochrome P-450 inhibitors on macrophage-induced oxidative modification of low density Lipoproteins

   
Dushkin M.I., Zenkov N.K., Pivovarova E.N., Lyubimov G.Yu., Menshikova Ye.B.
Type: Experimental study
PubMed Id: 8783470
Year: 1996 vol: 42  issue:1  pages: 23-30
Abstract: Unlike other cytochrome P450-dependent oxygenase inhibitors, ketoconazole has been shown to suppress the murine macrophage-mediated oxidative modification of human low-density lipoproteins (LDL) in a dose-dependent manner. The benzo[alpha]pyrene-induced microsomal monooxygenase activity was accomplished by a 1,5-fold increase in LDL oxidation by macrophages, ketokonazole (20 mu), methoxalene (20 mu), and alpha-naphthaflavone (50 mu). Ketoconazole was also effective in inhibiting macrophageal NADPH oxidase and LDL autooxidation induced by Fe2+ rather than Cu+, which is likely to be associated with its ability to act as a chelator of free and heme-bound iron ions.
Download PDF:
Reference: Dushkin M.I., Zenkov N.K., Pivovarova E.N., Lyubimov G.Yu., Menshikova Ye.B., Effects of cytochrome P-450 inhibitors on macrophage-induced oxidative modification of low density Lipoproteins, Voprosy meditsinskoi khimii, 1996, vol: 42(1), 23-30.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)