Voprosy meditsinskoi khimii (ISSN 0042-8809)

The study of the in vitro effect of selenium on formation of active oxygen species and lipid peroxidation in rat liver microsomes

   
Lashneva N.V., Karge E.E., Knells U.U., Klinger V.V., Splinter F.K., Tutelian V.A
PubMed Id: 9148594
Year: 1996 vol: 42  issue:2  pages: 119-124
Abstract: In vitro influence of sodium selenite on cytochrome P-450-dependent formation of active oxygen species on lipid peroxidation (LPO) in rat liver microsomes was studied. Sodium selenite (10(-6)-10(-3) M) did not influence rates of NADPH/Fe-induced formation of active oxygen species (O2.-, OH., H2O2) and NAPDH-dependent LPO. Only at 10(-3) M selenite caused significant decrease in production of hydrogen peroxide in microsomes. Data obtained suggest that sodium selenite at physiological concentrations does not influence formation of active oxygen species by cytochrome P-450 and the rate of enzymatic LPO in rat liver microsomes.
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Reference: Lashneva N.V., Karge E.E., Knells U.U., Klinger V.V., Splinter F.K., Tutelian V.A, The study of the in vitro effect of selenium on formation of active oxygen species and lipid peroxidation in rat liver microsomes, Voprosy meditsinskoi khimii, 1996, vol: 42(2), 119-124.
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