Voprosy meditsinskoi khimii (ISSN 0042-8809)

Ability of CO2 to inhibit the generation of superoxide anion-radical by cells and its biomedical importance

   
Kogan A.Kh., Grachev S.V., Eliseeva S.V., Bolevich S.S.
Type: Experimental study
PubMed Id: 9139450
Year: 1996 vol: 42  issue:3  pages: 193-202
Abstract: The study was carried out on blood phagocytes and alveolar macrophages of 96 persons, cells of inner organs and tissue phagocytes (liver, brain, myocardium, lungs, kidneys, stomach, skeletal muscles), as well as on mitochondria of the liver of 186 non-linear white mice. Generation of active oxygen forms (AOF) was evaluated by various methods with CO2 directly affecting the cells and bioptates and indirectly the whole organism. The results show that CO2 with tension close to that of the blood (37.0 mm Hg) and at higher tensions (60 and 146 mm Hg) is a powerful inhibitor of AOF generation by human and animal cells, as well as by liver mitochondria of mice. The data obtained allow to explain, in terms of AOF role, a number of physiological and pathophysiological (medical) CO2 effects.
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Reference: Kogan A.Kh., Grachev S.V., Eliseeva S.V., Bolevich S.S., Ability of CO2 to inhibit the generation of superoxide anion-radical by cells and its biomedical importance, Voprosy meditsinskoi khimii, 1996, vol: 42(3), 193-202.
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