Voprosy meditsinskoi khimii (ISSN 0042-8809)

Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A

   
Panova N.G., Veselovskaya N.V., Medvedev A.E.
PubMed Id: 9273781
Year: 1997 vol: 43  issue:3  pages: 172-176
Abstract: Pathways of 4-hydroxyphenylethanol formation were studied in the bovine brain. Incubation of brain homogenates with tyramine or tyrosine increased 4-hydroxyphenylethanol content only in the presence of NADH. Tyramine produced more pronounced augmentation of 4-hydroxyphenylethanol content than tyrosine. Tyrosine preparations were not contamined with tyramine. This suggests that 4-hydroxyphenylethanol may be formed from tyramine and tyrosine in NADH-dependent process. Preincubation of homogenates with 0.1 mM pargyline completely inhibited monoamine oxidases A and B and prevented NADH-dependent formation of 4-hydroxyphenylethanol from tyramine. The latter suggests that MAO is involved in formation of 4-hydroxyphenylethanol.
Download PDF:
Reference: Panova N.G., Veselovskaya N.V., Medvedev A.E., Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A, Voprosy meditsinskoi khimii, 1997, vol: 43(3), 172-176.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)