Voprosy meditsinskoi khimii (ISSN 0042-8809)

Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases

   
Matyushin B. N., Loginov A. S., Tkachev V. D.
PubMed Id: 9312941
Year: 1997 vol: 43  issue:4  pages: 256-260
Abstract: Repression of cytochrome P450- dependent hydrohylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione- dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
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Reference: Matyushin B. N., Loginov A. S., Tkachev V. D., Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases, Voprosy meditsinskoi khimii, 1997, vol: 43(4), 256-260.
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