Voprosy meditsinskoi khimii (ISSN 0042-8809)

Molecular-biological aspects of the interaction of the nervous and immune systems

   
Korneva E.A., Golovko O.I., Kazakova T.B.
PubMed Id: 9446322
Year: 1997 vol: 43  issue:5  pages: 321-329
Abstract: The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed. The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied. The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown. The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.
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Reference: Korneva E.A., Golovko O.I., Kazakova T.B., Molecular-biological aspects of the interaction of the nervous and immune systems, Voprosy meditsinskoi khimii, 1997, vol: 43(5), 321-329.
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