Voprosy meditsinskoi khimii (ISSN 0042-8809)

Oncopathology: the genes and enzymes of xenobiotic-metabolizing system

   
Lyakhovich V.V., Vavilin V.A., Gutkina N.I., Laktionova I.P., Makarova S.I., Mitrofanov D.V., Ostashevsky V.A., Chasovnikova O.B.
PubMed Id: 9446323
Year: 1997 vol: 43  issue:5  pages: 330-338
Abstract: The paper presents the results of study on polymorfisms of xenobiotic biotransformationenzymes (CYP1A1, glutathione S-transferase M1 and N-acetyltransferase 2)and p53 tumor suppressor protein in patients with lung, stomach and intestinecancer. The frequency of CYP1A1-Val allele in all studied cancer groupswas 3 to 5 times higher than in healthy control group. The carriers ofhomozygous glutathione S-transferase M1 gene deletion and slow acetylatorphenotype were also of higher lung cancer risk. The substantial increasein slow acetylator phenotype frequency was shown also in the group of intestinecancer patients. The p53 Arg/Pro polymorphism study revealed the elevatedfrequency of Arg allele in lung and stomach cancer groups. The risk oflung cancer for the carriers of susceptible alleles depended on the ageand smoking status of the patients. The results testify to a high possibilityof studied polymorphic genes to be the markers of susceptibility to oncopathologies.
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Reference: Lyakhovich V.V., Vavilin V.A., Gutkina N.I., Laktionova I.P., Makarova S.I., Mitrofanov D.V., Ostashevsky V.A., Chasovnikova O.B., Oncopathology: the genes and enzymes of xenobiotic-metabolizing system, Voprosy meditsinskoi khimii, 1997, vol: 43(5), 330-338.
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