Voprosy meditsinskoi khimii (ISSN 0042-8809)

Oxidate modification of monoamine oxidase activities

Medvedev A.E., Tipton K.F.
PubMed Id: 9503564
Year: 1997 vol: 43  issue:6  pages: 471-481
Abstract: Oxidative modification of monoamine oxidases (MAO) accompanied by alteration of their substrate specificity and sensitivity to specific inhibitors was discovered by Professor V.Z. Gorkin more than 30 years ago. The mechanism of this phenomenon includes oxidation of SH groups of the enzyme. Oxidative modification of MAO is also accompanied by increased sensitivity to limited proreolysis. Modification of MAO was found in many pathological states, however, elucidation of biological role of this phenomenon requires further investigations.
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Reference: Medvedev A.E., Tipton K.F., Oxidate modification of monoamine oxidase activities, Voprosy meditsinskoi khimii, 1997, vol: 43(6), 471-481.