Voprosy meditsinskoi khimii (ISSN 0042-8809)

GABA-ergic system in protection against excitatory kynurenines

Lapin I.P.
PubMed Id: 9503572
Year: 1997 vol: 43  issue:6  pages: 548-552
Abstract: Protection against the excitatory action of L-kynurenine and quinolinic acid in mice is related to the activation of GABA-B and dopamine receptors of the brain and to much lesser degree to the activation of GABA-A receptors. It is hardly believable that the anticonvulsant effect of phenibut (beta-phenyl-GABA), baclofen (CL-phenibut), sodium hydroxybutyrate and taurine against seizures induced by these two kynurenines is determined by alterations in metabolism of GABA.
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Reference: Lapin I.P., GABA-ergic system in protection against excitatory kynurenines, Voprosy meditsinskoi khimii, 1997, vol: 43(6), 548-552.