Voprosy meditsinskoi khimii (ISSN 0042-8809)

Analysis of molecular microheterogeneity of the glycoproteins from plasma of a patient with syalidosis

   
Zakharova E.T., Puchkova L.V., Shavlovsky M.M., Neuimina M.V., Rujdi E.P., Gaitskhoki V.S.
PubMed Id: 9575619
Year: 1998 vol: 44  issue:1  pages: 98-105
Abstract: Using specific polyclonal monovalent antibodies, the molecular microheterogeneity of acute phase proteins: orosomucoid, alpha1-antitrypsin and ceruloplasmin, circulating in peripheral blood of a healthy donor and a patient with a hereditary deficiency of lysosomal neuraminidase (syalidosis I or the cherry stone syndrome), was analyzed by use of 2D electrophoresis. The specific distinctions due to a deficiency [caused by a deficiency] of lysosomal neuraminidase were revealed in the population of ceruloplasmin molecules, but not in the molecules of alpha1-antitrypsin and orosomucoid (alpha 1-acid glycoprotein). The molecular genetic bases of molecular microheterogeneity of some plasma glycoproteins and the possible use of natural models in studies of GP's functional role and the pathways of its transfer after internalization into non-hepatocytic (?) cells are discussed.
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Reference: Zakharova E.T., Puchkova L.V., Shavlovsky M.M., Neuimina M.V., Rujdi E.P., Gaitskhoki V.S., Analysis of molecular microheterogeneity of the glycoproteins from plasma of a patient with syalidosis, Voprosy meditsinskoi khimii, 1998, vol: 44(1), 98-105.
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