Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effects of prenatal gamma-irradiation on the functional properties of rat liver adenylyl cyclase

   
Chubanov V.S., Rogov I.I., Sholukh M.V., Konoplya E.F.
PubMed Id: 9634716
Year: 1998 vol: 44  issue:2  pages: 145-150
Abstract: In the present work the effects of long-term prenatal gamma-irradiation (0.5 Gy) on the glucagon signalling through adenylyl cyclase have been investigated. In utero gamma-irradiation resulted in the increase of basal and GTP-stimulated adenylyl cyclase activity, whereas, the adenylyl cyclase response to glucagon was essentially reduced. The comparison of kinetic constants estimated from dose-response data for GTP and glucagon suggests that prenatal chronic irradiation prompted (i) the decrease in rate of GTP hydrolysis on Gs-protein; (ii) the reduction of glucagon potency to accelerate the exchange GDP for GTP on Gs-protein.
Download PDF:
Reference: Chubanov V.S., Rogov I.I., Sholukh M.V., Konoplya E.F., Effects of prenatal gamma-irradiation on the functional properties of rat liver adenylyl cyclase, Voprosy meditsinskoi khimii, 1998, vol: 44(2), 145-150.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)