Voprosy meditsinskoi khimii (ISSN 0042-8809)

The duel reciprocal regulation of succinate oxidation in heart and liver mitochondria under pathologi

   
Saakyan I.R., Saakyan A.G.
PubMed Id: 9634717
Year: 1998 vol: 44  issue:2  pages: 151-157
Abstract: The phenomenon of the dual reciprocal regulation of succinate dependent 2H+/Ca2+ exchange was studied in heart and liver mitochondria of experimental animals (allogenic heart transplantation in rat; myocardium infarction in rabbits; pulmonary arteria coarctation in dogs) and in liver bioptates from patients with stomach ulcer. Under pathology two coupled but opposite changes (simultaneous activation and inhibition) in succinate dependent Ca2+ transport occur. The inhibition of Ca2+ transport was detected by its elimination with glutamate, being mostly pronounced after cycle of ADP phosphorylation added to suspension of mitochondria. The treatment of animal with 2-oxoglutarate abolished this inhibition. This was not observed in healthy animals. The described phenomenon can prevent hyperactivation of succinate oxidation under strong pathological (distress) influences.
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Reference: Saakyan I.R., Saakyan A.G., The duel reciprocal regulation of succinate oxidation in heart and liver mitochondria under pathologi, Voprosy meditsinskoi khimii, 1998, vol: 44(2), 151-157.
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