Voprosy meditsinskoi khimii (ISSN 0042-8809)

The contents of monoamines under hypobaric hypoxia and the protective effect ofpyrazidol

   
Goroshinskaya I.A., Neskubina I.V.
PubMed Id: 9703624
Year: 1998 vol: 44  issue:3  pages: 248-255
Abstract: The effects of single acute hypoxia (9000 m above the sea level, 3h) and intermittent hypoxia (5000 m 4 h daily during 3 and 10 days) were studied. Acute hypoxia was characterized by the increase in the content of brain serotonin, dopamine and norepinephrine accompanied by a decrease of deaminated product. The increase of monoamine contents in hypothalamus and adrenals during initial stage caused to considerable extent by their deamination and the monoamine decrease under 10-day hypoxia were typical for intermittent hypoxia. The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state.
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Reference: Goroshinskaya I.A., Neskubina I.V., The contents of monoamines under hypobaric hypoxia and the protective effect ofpyrazidol, Voprosy meditsinskoi khimii, 1998, vol: 44(3), 248-255.
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