Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antithrombotic activity of complexes between superoxide dismutase and chondroitinsulfate at the arterial injury in rats

   
Maksimenko A. V., Tischenko E. G., Golubykh V. L.
PubMed Id: 9845922
Year: 1998 vol: 44  issue:4  pages: 353-361
Abstract: The comparative antithrombotic activity of superoxide dismutse and chondroitin sulfatein the form of covalent or noncovalent complexes was studied on the rat arterialthrombosis induced by treatment of vessel with ferrous chloride solution. The covalentconjugate between superoxide dismutase and chondroitin sulfate has been shown to exert thehighest antithrombotic effect. The higher antithrombotic activity of covalent conjugate isstipulated by its coupling on the glycocalyx of vascular wall and by the stability of thecovalent bond between superoxide dismutase subunits and chondroitin sulfate.
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Reference: Maksimenko A. V., Tischenko E. G., Golubykh V. L., Antithrombotic activity of complexes between superoxide dismutase and chondroitinsulfate at the arterial injury in rats, Voprosy meditsinskoi khimii, 1998, vol: 44(4), 353-361.
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