Voprosy meditsinskoi khimii (ISSN 0042-8809)

The study of phospholipid synthesis in liver of mice with alloxan diabetes

   
Saprykina E.V., Kozlov Y. A., Sosnina N.V., Baikov A.N., Novitsky V.V.
PubMed Id: 9845925
Year: 1998 vol: 44  issue:4  pages: 376-379
Abstract: The essential decrease of the rate of turnover of phosphatidic acids(PA), polyglycerophosphates (PGP) and their lysoderivatives (LPGP), sphinigomyelin (SM)and lysophosphatidylcholine (LPC), phosphatidyletnanolamine (PEA) was found in male miceof balb/c strain with subacute alloxan diabetes (glucose concentration in the blood wasnot less than 14 mmol/l) during examination of phospholipid metabolism in the liver by therate of 3H-acetate and 14C-palmitate incorporation intocorresponding chromatographic phospholipid fractions. On the contrary, turnover ofphosphatidilcholine (PC) significantly increased. The of main structural phospholipidcomponents of hepatocyte cellular membranes -PEA and PC - were found to bedecreased by 41 and 32%, respectively . LPGP and PA levels decreased to a lesser extent.The level of PGP, SM, phosphatidylinositol and LPG did not differ from the control level.
Download PDF:
Reference: Saprykina E.V., Kozlov Y. A., Sosnina N.V., Baikov A.N., Novitsky V.V., The study of phospholipid synthesis in liver of mice with alloxan diabetes , Voprosy meditsinskoi khimii, 1998, vol: 44(4), 376-379.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)