Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of carnosine and its derivative N-acetyl-carnosine on the stability of red blood cells from abstinent alcoholic patients

   
Prokopieva V.D., Bohan N.A., Jonson P., Boldyrev A.A.
PubMed Id: 9916263
Year: 1998 vol: 44  issue:5  pages: 474-478
Abstract: The effects of carnosine, a natural dipeptide, and itsderivative, N- acetyl-carnosine (Ac-carnosine), on the stabilityand shape of red blood cells obtained from abstinent alcoholicswas studied. In the presence of both carnosine and Ac-carnosine,the erythrocytes of abstinent alcoholics show a statisticallysignificant increase in their ability to resist acidic hemolysis.Investigations of microscope pictures also show that carnosineand Ac-carnosine have beneficial effects on the pathologicalstate of abstinent alcoholic erythrocytes. The addition ofcarnosine and Ac-carnosine resulted in the normalization of cellmorphology (in 12 and 17 out of 30 cases, respectively). Theseresults may be due to the stabilizing and regenerating ability ofthese compounds on alcoholic erythrocytes.
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Reference: Prokopieva V.D., Bohan N.A., Jonson P., Boldyrev A.A., Effect of carnosine and its derivative N-acetyl-carnosine on the stability of red blood cells from abstinent alcoholic patients, Voprosy meditsinskoi khimii, 1998, vol: 44(5), 474-478.
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